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Update modeling-foundations.rst
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mbrush authored Oct 8, 2024
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Evidence Line Representation
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Some users of the VA-Spec want to represent curated lines of evidence that describe how a particular set of information (e.g. specific data from a published study, or subset of data items from a dataset) is interpreted as evidence as supoprting or disputing a possible fact that they ultimately want to be able to assert about a variant.
Some users of the VA-Spec want to represent curated lines of evidence that describe how a particular set of information (e.g. specific data from a published study, or subset of data items from a dataset) is interpreted as evidence supoprting or disputing a possible fact that they ultimately want to be able to assert about a variant.

For example, that some set of allele frequency data items from gnomAD represents a *moderate* argument *supporting* the pathogenicity of a particular variant for a particular disease. Many organizations 'pre-curate' such arguments so that they can be tracked and efficiently and transparently combined to assert a final conclusion once sufficient evidence exists - e.g. that a variant is definitively pathogenic for some condition.

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